Antigen discrimination by T cells relies on size-constrained microvillar contact.
Edward Jenkins,
Markus Körbel,
Caitlin O'Brien-Ball,
James McColl,
Kevin Y Chen,
Mateusz Kotowski,
Jane Humphrey,
Anna H Lippert,
Heather Brouwer,
Ana Mafalda Santos,
Steven F Lee,
Simon J Davis,
David Klenerman
Apr 17, 2023
T cells use finger-like protrusions called 'microvilli' to interrogate their targets, but why they do so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer of large molecules forming a...